The 2021–22 Washington State Cougars women's basketball team represented Washington State University during the 2021–22 NCAA Division I women's basketball season.

The Cougars were led by fourth-year head coach Kamie Ethridge and they played their home games at Beasley Coliseum as members of the Pac-12 Conference.

The Cougars finished conference play with a 9–10 record.

The Cougars received an at large bid to the 2021 NCAA Division I women's basketball tournament.

They lost in the first round to the #8 seed South Florida and were eliminated.