The 2021–22 Western Sydney Wanderers season was the club's tenth season since its establishment in 2012, and participated in the A-League Men for the tenth time.

On 30 January 2022, it was announced that manager Carl Robinson had been sacked.

[1] The following day, Marko Rudan was appointed as manager until the end of the season.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Cancelled or postponed Updated to match played 13 May 2022Source: Competitions