Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Wigan Athletic announced friendlies against Oldham Athletic,[41] AFC Fylde,[42] Bootle,[43] Stoke City[44] and Preston North End[45] as part of their pre-season preparations.

Source: [citation needed] The league fixtures were revealed on 24 June 2021.

[55] Wigan were drawn into Northern Group C alongside Crewe Alexandra, Shrewsbury Town and Wolverhampton Wanderers U21s.

[57][58] In the knock-out stages, they were drawn away to Oldham Athletic in the third round[59] at home to Arsenal U21 in the quarter-final.