[1][2][3] The club's pre-season schedule included friendlies against Crewe Alexandra, Real Betis, Stoke City, Coventry City and Celta Vigo, in addition to two friendlies behind closed doors against Forest Green Rovers and Al Shabab.

[4] On July 12, Wanderers confirmed a sixth pre-season match, against Las Palmas.

[5] Source: [citation needed] The provisional fixture list was released on 16 June 2021, but was subject to change in the event of matches being selected for television coverage or police concerns.

[7] As a Premier League team, Wolves entered the competition at the third round stage, and were drawn at home to Sheffield United.

[14] Note: In group stage matches which were level at the end of 90 minutes, a penalty shoot-out was held, with the winner earning a bonus point.