The 2021–22 Women's EHF Champions League was the 29th edition of Europe's premier club handball tournament, running from 11 September 2021 to 5 June 2022.

Vipers Kristiansand defended their title after a finals win over Győri Audi ETO KC.

The teams were paired against each other in two-legged home-and-away matches, with the aggregate winners qualifying to the next round.

A total of 21 teams from 15 countries submitted their application for a place in the competition's group stage before the deadline of 21 June 2021.

[2][3] The final list of 16 participants was revealed by the EHF Executive Committee on 29 June 2021.