[46] Due to Derby County's financial irregularities from previous seasons, an interchangeable fixture list was originally made between Derby County in the Championship and Wycombe Wanderers in League One in case of any retrospective points deductions to be awarded for the 2020–21 season.

[47] However, on 2 July 2021, it was confirmed that Wycombe Wanderers would remain in League One after the EFL decided not to appeal against the Independent Disciplinary Commission's ruling of a £100,000 fine against Derby County.

[56][57] Wycombe were drawn into Southern Group C alongside Aston Villa U21s, Burton Albion and Milton Keynes Dons.

As one of three EFL clubs competing in the Berks & Bucks FA Senior Cup, alongside Milton Keynes Dons and Reading, Wycombe will enter the competition in the quarter-finals as they did back in the 2019–20 competition, which was cancelled due to the COVID-19 pandemic.

Wycombe Wanderers were drawn against Spartan South Midlands League Division One side Long Crendon.