The 2021–22 Xavier Musketeers men's basketball team represented Xavier University during the 2021–22 NCAA Division I men's basketball season as a member of the Big East Conference.

They lost in the first round of the Big East tournament to Butler.

The team received an at-large bid to the National Invitation Tournament where they defeated Cleveland State, Florida, Vanderbilt, and St. Bonaventure to advance to the championship game.

Head coach Travis Steele was fired on March 16, 2022, the day after the first win in the NIT.

In a season limited due to the ongoing COVID-19 pandemic, the Musketeers finished the 2020–21 season 13–8, 6–7 in Big East play to finish tied for seventh place.