The 2021–22 season was the 31st season of competitive association football in Ukraine since dissolution of the Soviet Union.

The Ukrainian Premier League and other sporting competitions were abandoned on 26 February 2022 following the Russian invasion of Ukraine and declaration of martial law in the country.

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Note: For all scratched clubs, see section Clubs removed for more details The following displays the location of teams.

Note: For the scratched club, see section Clubs removed for more details This is a list of managerial changes among Ukrainian professional football clubs: