The Crimson Tide were led by Patrick Murphy in his twenty-second season, and played their home games at Rhoads Stadium.

They advanced to their 13th 2021 Women's College World Series, where they were eventually defeated by Florida State in the semifinals.

[3] Pitchers Catchers Outfielders Infielders Utility Date m/dd is for last scheduled game of series.

Source: 2021 SEC softball game results, 2021 SEC softball schedule Updated for entire regular season.

[5][6]Tiebrkrs: FLA>ARK ALA common.