It was introduced as a response to the COVID-19 pandemic[1] and was held at the Algarve International Circuit in Portimão on 7 November 2021.

In the MotoGP class, Ducati secured its second consecutive Constructors' Championship.

[2] In the Moto3 class, Pedro Acosta won the Riders' Championship after main title rival Dennis Foggia crashed on the last lap after being hit by Darryn Binder.

Acosta is also the second youngest rider ever to win a world championship, just one day older than Capirossi.

[7] Below are the standings for the top five riders, constructors, and teams after the round.