The season began on August 28, 2021, and ended with the 2021 Pac-12 Championship Game on December 3, 2021, at Allegiant Stadium in Paradise, Nevada.

2021 Pac-12 Spring Football and number of signees on signing day: North Division South Division The Pac-12 conducted its 2021 Pac-12 media days at the Loews Hollywood Hotel, in Hollywood, California, on July 27, 2021 (Pac-12 Network).

[4] The teams and representatives in respective order were as follows: † Washington State Head Coach Nick Rolovich did not attend the conference, and instead participated remotely.

Below are the results of the media poll with total points received next to each school and first-place votes in parentheses.

[5] ‡Arizona State's Michael Turk announced his intention to transfer after the media voting window ended.

First Team †California's Michael Saffell announced his medical retirement after the media voting window ended.

‡Arizona State's Michael Turk announced his intention to transfer after the media voting window ended.

All Pac–12 Honorable Mention (received votes from four or more members of the media): There was one coaching change before the 2021 season.

[35] Mario Cristobal accept the coaching vacancy at Miami (FL) on December 6, finishing the season with a 10−3 record.

[36] He was replaced for the Alamo Bowl on interim basis by passing game coordinator and wide receivers Bryan McClendon.

The Pac-12 champion are also eligible for the College Football Playoff if they are among the top four teams in the final CFP ranking.

The following individuals received postseason honors as voted by the Pac-12 Conference football coaches at the end of the season.

Notes: Honorable mentions Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources.