The 2021 season for Alpecin–Fenix was the 13th season in the team's existence, the third as a UCI ProTeam, and the second under the current name.

[1] As the best performing UCI ProTeam in the 2020 season, Alpecin–Fenix were guaranteed invitations to all events in the 2021 UCI World Tour.

[2] The team finished the season once again as the best UCI ProTeam, ensuring UCI World Tour invitations in 2022.

[3]