The Lions failed to improve upon their 5–13 record from 2019 and were eliminated from playoff qualification on November 12, 2021, following a week 15 loss to the Calgary Stampeders.

[3] The Lions held their training camp at Hillside Stadium in Kamloops, British Columbia for the 11th consecutive season.

[9][10] There had been speculation that his departure from the organization was related to the grievance filed by starting quarterback Mike Reilly who was guaranteed $250,000 in 2020, despite the season being cancelled.

[11][12] On December 7, 2020, it was announced that head coach Rick Campbell and director of football operations Neil McEvoy were promoted to co-general managers.

[8] [18] The Lions initially had a schedule that featured 18 regular season games beginning on June 12 and ending on October 29.