This was the first edition of the tournament, primarily created due to the one-week delay of the 2021 French Open.

[1] Novak Djokovic won the title, defeating Alex Molčan in the final, 6–4, 6–3.

[2] It was Djokovic's third title ever in a tournament held in Serbia (excluding the Davis Cup).

The top four seeds receive a bye into the second round.