The 2021 Córdoba Open was a men's tennis tournament played on outdoor clay courts.

It was the third edition of the Córdoba Open, and part of the ATP Tour 250 series of the 2021 ATP Tour.

It took place at the Estadio Mario Alberto Kempes in Córdoba, Argentina, from 20 February until 28 February 2021.

[3] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: