The draw for this edition of the tournament was held at the CAF headquarters in Cairo, Egypt on 29 September 2021 at 17:00 CAT (15:00 UTC).

As club competition hosts, Wadi Degla was allocated to position A1.

Owing to the COVID-19 pandemic and its associated travel restrictions, the matches were played behind closed doors.

[10] The CAF Women's Champions League technical study group selected the following as the best of the tournament.

[10] Per statistical convention in football, matches decided in extra time are counted as wins and losses, while matches decided by a penalty shoot-out are counted as draws.