The Stampeders qualified for the playoffs for the 16th straight year following their week 15 victory over the BC Lions on November 12, 2021.

[1] However, the team lost the West Semi-Final in double overtime to the Saskatchewan Roughriders by a score of 33–30.

[3][4] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[8] Due to the shortening of the season, the CFL confirmed that pre-season games would not be played in 2021.

[5] [11] The Stampeders initially had a schedule that featured 18 regular season games beginning on June 12 and ending on October 29.