The 2021 Campeón de Campeones was a Mexican football match that took place on 18 July 2021.

The match is the sixth edition of the modern Campeón de Campeones, contested by the Liga MX season's Apertura and Clausura champions.

[1] The match took place at Dignity Health Sports Park in Carson, California, hosting for the fifth time.

Like previous editions, the Campeón de Campeones was contested at a neutral venue in the United States.

[3] Assistant referees:[7] Christian Espinosa Zavala (Mexico City) José Ibrahim Martínez (Guerrero) Fourth official:[7] Marco Antonio Ortiz (Durango) Video assistant referee:[7] Jorge Isaac Rojas (Mexico City) Assistant video assistant referee:[7] Eduardo Galván Basulto (Mexico City)