The 2021 Campeonato Internacional de Tênis de Campinas was a professional tennis tournament played on clay courts.

It was the tenth edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Campinas, Brazil between 15 and 21 November 2021.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: