[2][3] Universidad Católica were the defending champions, and won their fourth straight title in the competition, and sixteenth overall, after a 3–0 away win over Everton on 4 December 2021, the last matchday of the season.

ANFP considered playing a tournament with two stages, starting from late March.

[5] On 2 March 2021, ANFP's Council of Presidents voted to approve the format for the season.

[7][8] Both promoted teams replaced Coquimbo Unido, Deportes Iquique, and Universidad de Concepción, who were relegated to Primera B at the end of the 2020 season.

Source: Soccerway The team placed 15th in the season table (Huachipato) played the winners of the Primera B play-offs (Deportes Copiapó) in a double-legged series, with the winner earning the right to play in the top flight for the following season.