The fourth running of the women's event of the Three Days of Bruges–De Panne, also called Oxyclean Classic Brugge–De Panne, will be held on 25 March 2021.

It is the third race of the 2021 UCI Women's World Tour.

All nine UCI Women's WorldTeams and fourteen UCI Women's Continental Teams competed in the race.

Cogeas–Mettler–Look were expected to participate, but they withdrew shortly before the race.

[1][2] UCI Women's WorldTeams UCI Women's Continental Teams This cycling race article related to Belgian cycling is a stub.