[1] On 22 March 2021, during a virtual meeting of its Council, CONMEBOL confirmed adjustments in the tournament regulations, several of these related to the player rosters, taking into account the conditions imposed by the COVID-19 pandemic.
Taking into consideration the fact that matchdays 7 and 8 of CONMEBOL's FIFA World Cup qualifiers were played only a few days before the start of the tournament, the final list of up to 28 players per national team could be submitted to CONMEBOL by 10 June 2021, 12:00 PYT (UTC−4), three days prior to the opening match of the tournament.
[4] Once the final lists were registered, teams were only permitted to make replacements in cases of serious injuries up to 24 hours before their first match.
The numbers of caps and goals listed for each player do not include any matches played after the start of the tournament.
After the team's last group stage match, defender Guillermo Maripán withdrew injured and was replaced by Diego Valencia on 27 June.
[14][15][16] Head coach: Eduardo Berizzo Paraguay announced their final squad of 28 players on 10 June 2021.
After the team's second group stage match, defender Felipe withdrew injured and was replaced by Léo Ortiz on 26 June.
[28] Midfielder and captain Tomás Rincón and goalkeeper Rafael Romo tested positive for SARS-CoV-2 and were replaced by Francisco La Mantía and Luis Romero respectively on 12 June.
After the team's last group stage match, midfielder Damián Díaz withdrew after testing positive for SARS-CoV-2 and was replaced by Carlos Gruezo on 29 June.
[32][33] Head coach: Ricardo Gareca Peru's 50-man provisional list was announced on 27 April 2021,[34] and was expanded to 60 players on 1 June 2021.