The 2021 Copa Constitució was the 29th edition of the Andorran national football knockout tournament.
The opening round of this edition of the cup was played on 17 February 2021.
[1] Inter Club d'Escaldes were the defending champions after winning the final over FC Santa Coloma by a score of 2–0.
[2] Eight clubs competed in the first round.
[6] The final was played between the winners of the semi-finals on 30 May 2021.