It was played at Wembley Stadium in London, England, on 25 April 2021, between Manchester City and Tottenham Hotspur,[3] having been originally scheduled to take place on 28 February 2021.

[12] In the fourth round they defeated fellow Premier League team Burnley 3–0 at Turf Moor with two goals from Raheem Sterling and one from Ferran Torres.

[16] On 25 September, it was confirmed that Tottenham had received a bye into the fourth round, due to Orient's inability to fulfil the fixture.

[19] In the semi-finals, Tottenham met the only non-Premier League side still playing up to this stage, Brentford of the EFL Championship.

[21] Presenter Laura Woods was joined by pundits Michael Dawson, Micah Richards and Jamie Redknapp, with match commentary by Martin Tyler and Gary Neville.

[33] Manchester City manager Pep Guardiola announced in his press conference ahead of the game that forward Sergio Agüero and midfielder Kevin De Bruyne would be fit enough to play, while Tottenham's interim manager, Ryan Mason, announced that he was going to take it "hour by hour" regarding Harry Kane's availability after he missed Spurs first match under Mason against Southampton.

The first chance fell to Manchester City when Raheem Sterling wrongfooted Serge Aurier and kept the ball in play and pulled it back for Phil Foden at the near post, he took his shot but fired it just wide of the target in the 7th minute.

In the 8th minute, Riyad Mahrez came forward again down the right, he lifted a good cross in the middle for Sterling, he flicked the header on but couldn't keep it down though and it went just over the bar.

In the 14th minute, it looked like a throw-in was heading straight out of play but Foden managed to keep it in, he pulled it back for Sterling in space in the middle, he turned before hitting a shot and Eric Dier threw himself in front of it to make the block.

In the 20th minute, Zack Steffen punched a corner away, but Spurs managed to keep hold of it, Harry Winks switched the play out to the left for Son Heung-min, who nodded it down for Toby Alderweireld on the edge of the box, he drilled a low shot to the near post but it was just wide of the target.

In the 27th minute, Sergio Reguilón was shown the game's first yellow card for late foul on Kevin De Bruyne.

In the 37th minute, City moved it brilliantly on the edge of the box where they played it between Sterling, Foden, De Bruyne, Fernandinho and finally out to Mahrez on the right.

In the 47th minute, Moura squared a ball to Giovani Lo Celso on the edge of the box and he took a touch before curling it towards the far bottom corner where Steffen pushed it away.

In the 74th minute, City went on the counterattack and Mahrez drove through midfield to get into space for a shot he hit his effort through the central defenders and Lloris got a strong hand to it to tip it away from goal.