The 2021 FIBA U18 Women's European Challengers were international basketball competitions which took place from 27 July to 1 August 2021, replacing the cancelled 2021 FIBA U18 Women's European Championship.

[1] The 2020 edition of FIBA U18 Women's European Championship was to be held in Heraklion, Greece but was postponed to 2021 due to COVID-19 pandemic.

Since the pandemic continued in 2021, the FIBA Europe decided to hold alternative format of competition to replace traditional format of U18 Women's European Championship where 16 or more teams gather in one place.

The Group B tournament was played in Klatovy, Czech Republic.

The Group C tournament was played in Heraklion, Greece.