The 2021 French Open Men's Singles final was the championship tennis match of the men's singles tournament at the 2021 French Open, contested by first-seed Novak Djokovic and fifth-seed Stefanos Tsitsipas.

[2] With the win, Djokovic won his 19th major and became the first man in the Open Era to achieve the Double Career Grand Slam.

[5] It marked the second consecutive year a man trailed by two sets in a major final yet rallied to win, following Dominic Thiem's victory at the 2020 US Open.

[11] It was a rematch of the previous year's final, and marked the third time in Nadal's career that he was defeated at the French Open, and was both his first semifinal loss at the event and the first time that Nadal had lost a match at the French Open after having won the first set.

[2] Djokovic had also come back from two-sets-to-love down in the fourth round against Lorenzo Musetti.