The 2021 Grote Prijs Jean-Pierre Monseré was the 9th edition of the Grote Prijs Jean-Pierre Monseré road cycling one-day race in Belgium.

It was a 1.1-rated event on the 2021 UCI Europe Tour.

The 202.1 kilometres (125.6 mi) long race started in Hooglede and finished in Roeselare.

The race was won by Belgian cyclist Tim Merlier of the Alpecin–Fenix team.

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