The 2021 Grote Prijs Jef Scherens was the 54th edition of the Grote Prijs Jef Scherens road cycling one day race in and around Leuven.

[1] It was held on 15 August 2021 as a 1.1 categorised race and was part of the 2021 UCI Europe Tour and the 2021 Belgian Road Cycling Cup.

The race course overlaps to a large part with that of the 2021 UCI Road World Championships, which are to be held a few weeks later.

The defending champion is sprinter Niccolò Bonifazio, who won the 2019 edition as no race was held in 2020 due to the COVID-19 pandemic in Belgium.

Besides Bonifazio (Team TotalEnergies), other sprinters present included Tim Merlier (Alpecin–Fenix), Baptiste Planckaert (Intermarché–Wanty–Gobert Matériaux), Nacer Bouhanni (Arkéa–Samsic) and Bryan Coquard (B&B Hotels p/b KTM).