The Tiger-Cats qualified for the playoffs for the third consecutive year following their week 14 win over the BC Lions on November 5, 2021.

[1] The team defeated the Montreal Alouettes and Toronto Argonauts in the playoffs to qualify for their 22nd Grey Cup game appearance.

[3][4] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[11] Due to the shortening of the season, the CFL confirmed that pre-season games would not be played in 2021.

[5] [12] The Tiger-Cats initially had a schedule that featured 18 regular season games beginning on June 10 and ending on October 29.