The 2021 Houston Cougars football team represented the University of Houston in the 2021 NCAA Division I FBS football season.

The Cougars played their home games at TDECU Stadium in Houston, Texas, competing in the American Athletic Conference.

They were led by third-year head coach Dana Holgorsen.

The American Athletic Conference preseason media poll was released at the virtual media day held August 4, 2021.

[1] Cincinnati, who finished the 2020 season ranked No.