The 2021 Indy Pro 2000 Championship was the 23rd season in series history.
An 18-round schedule was announced on October 21, 2020, featuring five permanent road courses, two street circuits, and two ovals.
[1] Danish Christian Rasmussen, driving for Jay Howard Driver Development, won the championship in the last race of the season at the Mid-Ohio Sports Car Course.
[2] * The race at Lucas Oil Raceway began on May 28, but was stopped and postponed to May 29 due to inclement weather.
* Following the cancellation of the Honda Indy Toronto, promoters replaced it with the second Mid-Ohio round.