The 2021 Royal Bernard Drôme Classic was the 8th edition of the Royal Bernard Drôme Classic cycle race.

It was held on 28 February 2021 as a category 1.Pro race on the 2021 UCI Europe Tour and the 2021 UCI ProSeries.

[2] For the first time since 2014, the race did not start and/or finish in Livron-sur-Drôme.

Instead, the race started and finished in nearby Eurre and featured five climbs, including a triple ascent of the Mur d'Eurre, the last of which summited with five kilometers left.

[1][3] It formed a pair of races on the same weekend with the 2021 Faun-Ardèche Classic, held on the previous day, with both races being organized by Boucles Drôme Ardèche.