It was held on indoor hard courts at the TD Garden in Boston, United States from 24 until 26 September.

Roger Federer was originally the first player to confirm his participation for Team Europe on 28 February 2020,[3] but withdrew on 15 August 2021 due to a right knee injury.

[9] Five days later, Denis Shapovalov, Félix Auger-Aliassime and Diego Schwartzman were the first players confirmed for Team World.

[10] On 13 August 2021, organizers announced that Olympic champion Alexander Zverev would join Team Europe.

Team Europe then announced its final line-up on 18 August 2021 with Stefanos Tsitsipas, Andrey Rublev and Casper Ruud also taking part.