The 2021 Lory Meagher Cup was the thirteenth edition of the Lory Meagher Cup since its establishment by the Gaelic Athletic Association in 2009 and is the fifth-tier of Hurling for senior county teams (the All-Ireland Senior Hurling Championship is the first-tier trophy).

It is contested by five GAA county teams ranked 28–32 in the 2021 All-Ireland Senior Hurling Championship.

Group B featured 2 teams who played a single fixture.

All-Ireland Senior Hurling Championship There was no direct qualification to the All-Ireland Senior Hurling Championship proper for Lory Meagher Cup teams.

They would be replaced by the bottom-placed team in the 2021 Nicky Rackard Cup.