[11] On February 12, 2021, the Dodgers traded pitcher Dylan Floro to the Miami Marlins in exchange for Alex Vesia and Kyle Hurt.

[12] On December 2, the Dodgers acquired relief pitcher Corey Knebel from the Milwaukee Brewers in exchange for a player to be named later or cash considerations.

[30] Pitcher Jimmy Nelson, in camp on a minor league contract, impressed enough in spring training that he was added to the 40-man roster on March 25.

Source: MLB Standings Grid – 2021 The Dodgers began their 2021 season with a four-game series against the Colorado Rockies at Coors Field.

Walker Buehler struck out four in six scoreless innings and Justin Turner hit a solo home run that accounted for all the scoring in the Dodgers 1–0 win.

[46] In the finale of the series, Bauer allowed only one run over six innings while striking out seven, becoming just the third Dodgers pitcher to record seven or more strikeouts in his first four games with the club.

[47] The Dodgers next played the Seattle Mariners in a two-game interleague series at T-Mobile Park, dropping the opener 4–3 from runs driven in by José Marmolejos and Taylor Trammell.

The Dodgers tied the game in the bottom of the seventh with back-to-back homers by A. J. Pollock and Sheldon Neuse but the Padres got a late run to take the opener, 3–2.

[69] After an off day, the Dodgers faced the Miami Marlins for a three-game weekend series, starting with a 9–6 win, highlighted by an eight run second inning.

[102] In the final game of the series, the Dodgers scored five runs in the third inning, which included a three-run homer by Albert Pujols, and built a 9–1 lead.

The bullpen collapsed in the eighth inning and let the Diamondbacks get back into the game but Kenley Jansen shut down the side in the ninth to preserve a 9–8 win.

[117] The Marlins won again the next day, 2–1, in 10 innings with the winning run scoring on a wild pitch by Blake Treinen and a throwing error on Will Smith.

Tony Gonsolin allowed only two hits in 5+1⁄3 innings while striking out seven while Austin Barnes solo homer was the only run scored in the game.

[143] In the next game, the Dodgers came from behind to win 5–3 thanks to a game-tying home run by Cody Bellinger in the seventh and a go-ahead two-run double by Chris Taylor in the eighth.

Julio Urías returned from a short stint on the injured list to allow only one hit in five scoreless innings while Smith homered and the Dodgers won 5–2.

[166] The Dodgers beat the Braves 4–3 on September 1 to sweep the series and move past the San Francisco Giants into first place in the National League West for the first time since April 28.

[167] The Dodgers traveled to Oracle Park on September 3 to play the Giants for three games with two teams tied for first place at the start of the series.

[174] The Dodgers returned home and beat the San Diego Padres, 3–0, behind seven shutout innings from Urías and a two-run homer by Max Muncy.

[177] In the following game, Clayton Kershaw returned to the mound for the first time since being placed on the injured list after his July 3 appearance and he struck out five while allowing one run in five innings against the Arizona Diamondbacks.

[193] In the next game, Julio Urías allowed only one run on one hit and two walks while striking out seven in 6+1⁄3 innings as he picked up his 20th win of the season in the Dodgers 8–3 victory.

The game remained tied until the bottom of the ninth when Chris Taylor hit a walk-off two-run home run off of Alex Reyes.

The Dodgers scored the first two runs in the second on RBI singles by Urías and Mookie Betts with the Giants getting one back in the bottom of the inning on a sacrifice fly by Donovan Solano.

The Dodgers then scored four runs in the sixth on back-to-back doubles by Cody Bellinger and A. J. Pollock and they added three more in the eighth on a Will Smith homer and RBI singles by Matt Beaty and Corey Seager off of relievers Zack Littell and Jarlin García.

Alex Wood and three relievers combined to hold the Dodgers scoreless for the second time in the series and the Giants took back the lead with a 1–0 victory.

Mookie Betts opened the game with a single, followed by a home run from Corey Seager, staking the Dodgers to an early 2–0 lead.

In the top of the seventh, the Dodgers had the bases loaded with two outs following two walks and a hit batsman; Taylor then drove in two runs with a double off of Luke Jackson, putting Los Angeles ahead, 4–2.

In the top of the ninth, Dansby Swanson singled, stole second, and was driven in by a Freeman ground rule double, extending Atlanta's lead to 6–2.

Pollock] led off the bottom of the second with a solo home run; he was followed by Albert Pujols who singled, then Chris Taylor homered to put the Dodgers ahead, 3–2.

The Braves' Tyler Matzek entered to pitch and struck out Pujols, Steven Souza Jr., and Mookie Betts to end the threat.

[349] Following the season, the Dodgers selected several top prospects to play for the Glendale Desert Dogs in the Arizona Fall League: Pitchers Bobby Miller, Landon Knack, Jeff Belge and Kyle Hurt, infielders Kody Hoese and Jacob Amaya and outfielder James Outman.