The 2021 Louisiana Tech Bulldogs football team represented Louisiana Tech University in the 2021 NCAA Division I FBS football season.

The Bulldogs played their home games at Joe Aillet Stadium in Ruston, Louisiana, and competed in the West Division of Conference USA (C-USA).

They were led by ninth-year head coach Skip Holtz.

The Bulldogs were predicted to finish third in the West Division.

Ballard Stadium, Norfolk, Virginia Second quarter Third quarter Fourth quarter at Protective Stadium, Birmingham, Alabama at Joe Aillet Stadium, Ruston, Louisiana Second quarter Third quarter Fourth quarter at Joe Aillet Stadium, Ruston, Louisiana at Rice Stadium, Houston, Texas