The 2021 Münsterland Giro (known as the Sparkasse Münsterland Giro for sponsorship reasons) was the 15th edition of the Münsterland Giro road cycling one day race, held mostly in the titular region of northwest Germany on 3 October 2021.

This edition was the race's first in the UCI ProSeries; the 2020 edition was expected to feature in the inaugural UCI ProSeries but was cancelled due to the COVID-19 pandemic.

[2] The 209-kilometre (130 mi) race started in Enschede, just across the border in the Netherlands.

The last hill of the race, the Vorbergshugel, was 0.7 kilometres (0.43 mi) long with an average gradient of 4.3 percent; it crested with just under 2 kilometres (1.2 mi) from the finish line in Nienberge on the outskirts of Münster.

Four teams did not enter a full squad of seven riders: Alpecin–Fenix, Israel Start-Up Nation, and Team SKS Sauerland NRW each entered six riders, while Bike Aid was the only team to enter five riders.