2021 Mexican League season

The league was contested by 18 teams, evenly divided in North and South zones.

[3] Veracruz returned to the league after a three year absence, when in 2018 the franchise was sold and moved to Nuevo Laredo.

[4] Starting from this season, there were four rounds of playoffs to define the champion.

Diablos Rojos del México won the series, 4–1.

Diablos Rojos del México won the series, 4–1.