The season was scheduled to begin September 2, 2021, and ended with the MAC Football Championship Game on December 4, 2021.

[23] Michigan co-defensive coordinator Maurice Linguist was later hired as Buffalo's new permanent coach.

[24] On July 14, Frank Solich announced his retirement from the head coach position at Ohio after 16 seasons with the school.

Tim Albin was promoted to head coach to fill Solich's vacancy.

The following individuals received postseason honors as voted by the Mid-American Conference football coaches at the end of the season.

Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources.