The Alouettes qualified for the playoffs on November 5, 2021, after the Hamilton Tiger-Cats defeated the BC Lions in week 14.

[1] The team's season was ended by the same Tiger-Cats following a 23–12 East Semi-Final loss in Hamilton.

[6][7] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[14] Due to the shortening of the season, the CFL confirmed that pre-season games would not be played in 2021.

[8] [15] The Alouettes initially had a schedule that featured 18 regular season games beginning on June 11 and ending on October 30.