The 2021 NCAA Division I baseball season play of college baseball in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began on February 19, 2021.
The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2021 NCAA Division I baseball tournament and 2021 College World Series.
The College World Series, consisting of the eight remaining teams in the NCAA tournament and held annually in Omaha, Nebraska, at TD Ameritrade Park Omaha, ended on June 30, 2021.
The Mississippi State Bulldogs won the tournament, and were named national champions.
Conferences that do not hold a tournament award their automatic bids to the regular-season champion.