The team was led by fourth-year head coach Scott Frost and played its games at Memorial Stadium in Lincoln, Nebraska.

[1] The 2021 Nebraska Cornhuskers were the first team in Division I history to lose nine games by single digits.

For the 2021 poll, Ohio State was voted as the favorite to win both the East Division and the Big Ten Championship Game.

[8] Below are the results of the annual Preseason Big Ten Player of the Year awards conducted by Cleveland.com.

[9][10] The Big Ten released a revised conference schedule on February 5, 2021 to correct home/away matchups that were altered from the 2020 COVID-stricken season.