The Wolf Pack were led by fifth–year head coach Jay Norvell and played their home games at Mackay Stadium.

Listed in the order they were released The Mountain West media days were held on July 21–22, 2021, at the Cosmopolitan in Paradise, Nevada.

The Wolf Pack were predicted to finish in first place in the MW West Division.

[11] The Wolf Pack had four players selected to the preseason All–Mountain West Team; three from the offense and one from the specialists.

[12] Offense Romeo Doubs – WR Carson Strong – QB Cole Turner – TE Specialists Brandon Talton – PK