They were led by second-year head coach Danny Gonzales.

Listed in the order they were released The Mountain West media days were held on July 21–22, 2021, at the Cosmopolitan in Paradise, Nevada.

The Lobos were predicted to finish in sixth place in the MW Mountain Division.

[3] The Lobos had one player selected to the preseason All–Mountain West Team; one from the defense.

Note: With the COVID-19 pandemic still ongoing, opponents and dates are subject to change.