The 2021 Oklahoma State Cowboys football team represented Oklahoma State University during the 2021 NCAA Division I FBS football season.

The Cowboys played their home games at the Boone Pickens Stadium in Stillwater, Oklahoma, and competed in the Big 12 Conference.

The team was led by seventeen-year head coach Mike Gundy.

Roster Last update: 8/8/22 at Boone Pickens Stadium • Stillwater, OK at Boone Pickens Stadium • Stillwater, OK at Albertsons Stadium • Boise, ID at Boone Pickens Stadium • Stillwater, OK at Boone Pickens Stadium • Stillwater, OK at Darrell K Royal–Texas Memorial Stadium • Austin, TX at Jack Trice Stadium • Ames, IA at Boone Pickens Stadium • Stillwater, OK at Milan Puskar Stadium • Morgantown, WV at Boone Pickens Stadium • Stillwater, OK at Jones AT&T Stadium • Lubbock, TX at Boone Pickens Stadium • Stillwater, OK at AT&T Stadium • Arlington, TX at State Farm Stadium • Glendale, AZ