The 2021 Old Dominion Monarchs football team represented Old Dominion University during the 2021 NCAA Division I FBS football season.

Ballard Stadium in Norfolk, Virginia, and competed in the East Division of Conference USA (C-USA).

On October 27, 2021, Old Dominion announced that this would be the last season for the team in C-USA, and they would join the Sun Belt Conference on July 1, 2022.

[1] On August 10, 2020, Old Dominion announced that they would cancel their 2020 FBS football season due to health, safety, and travel concerns for the COVID-19 pandemic.

[4][5] The 2021 schedule consisted of 6 home and 6 away games in the regular season.