PSG Talon was the PCS' representative at the 2021 Mid-Season Invitational and first seed at the 2021 World Championship.

Resurgence was relegated after a close series and Impunity Esports took their spot.

[3] Filipino team Liyab Esports, which finished ninth in both splits of the 2020 season, swept Panic Time from the Filipino qualifier in their relegation match and kept their spot.

ahq eSports Club announced on 6 January 2021 that it would no longer participate in the PCS.

[4] Xue "Dinter" Hong-wei, who was previously the jungler for Taipei Assassins and Hong Kong Esports, acquired ahq's spot and created a new team named Beyond Gaming.