The 2021 División Profesional season (officially the Copa de Primera TIGO-Visión Banco 2021 for sponsorship reasons) was the 87th season of the Paraguayan Primera División, the top-flight professional football league in Paraguay.
In the Torneo Apertura, Libertad secured their twenty-first league title with one match to spare following Nacional's loss to River Plate on 23 May,[3] whilst in the Torneo Clausura Cerro Porteño won their thirty-fourth league title after drawing with eventual runners-up Guaraní 2–2 on the last matchday played on 4 December.
[5] General Díaz and San Lorenzo were both relegated to the second tier at the end of the previous season after eight and two years in the top flight, respectively.
[37] Source: APF Sportivo Ameliano won 4–3 on aggregate and were promoted to Primera División.
On 14 December 2021 a ceremony was held at the Paraguayan Football Association's headquarters to announce the winners of the season awards (Premios de Primera), who were chosen based on voting by the managers of the 10 Primera División teams, local sports journalists, the APF's Referee Commission, the public as well as official statistics.