Coached by Brad Arthur and captained by Clinton Gutherson, they competed in the NRL's 2021 Telstra Premiership.

[1] Similar to the 2020, Parramatta started the 2021 season in good form winning nine of the opening ten games.

Towards the back end of the season however, Parramatta once again displayed inconsistent form and were hit with heavy losses against South Sydney and Manly.

In round 24, Parramatta produced the biggest upset of the season defeating Melbourne 22-10 who were on a 19-game winning streak.

The following week, they played Penrith in what would turn out to be the lowest scoring game of the season.