The International Racquetball Federation's 20th Racquetball World Championships was held in Guatemala City, Guatemala from November 29-December 6, 2021.

The defending champions were Rodrigo Montoya of Mexico in Men's Singles, Gabriela Martínez of Guatemala in Women's Singles, Mexicans Álvaro Beltrán and Daniel de la Rosa in Men's Doubles, and Bolivians Valeria Centellas and Yasmine Sabja in Women's Doubles.

Initially, players competed in separate groups over three days.

The results were used to seed players for an elimination round.

Team standings were based on points earned from the singles and doubles competitions.